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Abstract #0279

Semi-automated Fiber-based Analysis of Group Differences in DTI

Arlinghaus L, Ding Z, Anderson A, Park S, Li R, Dawant B, Lee J
Vanderbilt University

The definition of point-correspondence between subjects is a major challenge in the implementation of fiber-based (FB) analysis methods of DTI data. We have developed a FB analysis scheme which provides semi-automated seed point selection and point-correspondence definition based upon the co-registration of the diffusion tensor image spaces. This method was applied to a study of FA differences between control and schizophrenic subjects in the cingulum, uncinate, and arcuate fasciculi. We found our method to be consistent with the results of ROI and VB analysis.