Dynamic Magnetic Resonance Inverse Imaging of Human Brain Function
Lin F, Kwong K, Ahlfors S, Hamaleinen M, Wald L, Belliveau J
Massachusetts General Hospital
Inspired by electroencephalography (EEG) and magnetoencephalography (MEG) source localization, we develop MR Inverse Imaging (InI) to achieve an order-of-magnitude speed-up in dynamic MR measurements. Spatially resolved dynamic changes and associated statistical inference maps can be obtained with millisecond temporal resolution using spatial information encoded with the detector geometry of a 90-channel head array. We introduce the InI theoretical framework and demonstrate the InI in classical BOLD PRESTO fMRI with 20-ms temporal resolution. The InI approach can be combined with other MR contrast preparation mechanism for the ultra-fast characterization of functional contrast sources associated with neuronal activation.