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Abstract #0395

Quantitative MRI/MRS of Nonalcoholic Fatty Liver Disease (NAFLD)

Olynyk J, Palmer D, Akduman I, Balci G, Bialecki E, Brunt E, Neuschwander-Tetri B, Perman W
University of Western Austrailia

We performed quantitative MRI and MRS on 25 patients diagnosed with NAFLD in order to correlate the histologic measures of the disease (steatosis, inflammation and fibrosis) with the MRI and MRS parameters of calculated T1 and T2, percent fat, percent magnetization transfer (MT%), and diffusion coefficient (D). Significant changes in liver T1 were highly correlated with inflammation alone, significant percent fat correlated with decreased T1 and T2, significant changes in MT and D do not appear to correlate with histology. Summary: quantitative liver MRI/MRS is sensitive to changes due to disease, but the changes do not always correlate with histology.