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Abstract #0428

Amide Proton Transfer Imaging of Human Brain Tumors Distinguishes Tumor from Brain Tissue at the Periphery

van Zijl P, Zhou J, Schlosser M, Pomper M, Jones C
Kennedy Krieger Institute, Johns Hopkins University

In the amide proton transfer (APT) effect, endogenous mobile protein or peptide amide protons are saturated and exchange with free water protons, thereby reducing the measurable water signal. Ten brain tumor patients were scanned with APT, T2w, T1w, FLAIR and DWI imaging. The quantitative analysis showed that the APT contrast was able to distinguish active tumor from normal appearing white matter or peritumoral edema better than the standard clinical measures