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Abstract #0504

Heterogeneity of brain inflammation following human ischemic stroke: Evidence from USPIO -enhanced MRI

Saleh A, Ringelstein A, Jander S, Schroeter M
Heinrich Heine-University

Heterogeneity of stroke is regarded one of the main obstacles for establishing new therapeutic approaches. New methods are demanded to get additional in vivo pathophysiological information to tailor stroke therapy more individually. USPIO-enhanced MRI gives valuable new information after stroke. In an ongoing study. we found USPIO-enhancement in three out of nine patients in early post stroke MRI. USPIO enhancement is suggested to reflect divergent dynamics and spatial patterns of macrophage infiltration after stroke and may help to select patients suitable for studying anti-inflammatory therapeutic strategies after stroke.