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Abstract #0539

fMRI Measurement of CMRO2 Using a Comprehensive Biophysical Model: Compared with PET

Gao J, Fox P, Lin A
University of Texas Health Science Center at San Antonio

Mapping changes in the cerebral metabolic rate of oxygen (CMRO2)in human brain during neuronal activation has been performed using both PET and fMRI. It has been noted that the &[Delta]CMRO2/CMRO2measured by fMRI (based on a simplified biophysical model) in previous studies was significantly different both in its values and pattern of the frequency dependence when compared with those measured by PET. By using a recently developed and more comprehensive biophysical model and improved data acquisition strategy, the fMRI-determined CMRO2were re-evaluated and the new fMRI data shows substantial improvement in its agreement with previous PET results.