Potential of SPIO in the diagnosis of bone metastasis - preliminary examination for clinical application
Kato N, Fukuda Y, Tsuda N, Ando K, Ishikura R, Nakao N
Nihon Schering K.K.
In preliminary experiment using the model rabbits, we have reported that a superparamagnetic iron oxide (SPIO) enhanced magnetic resonance imaging (MRI) has a potential in the differential diagnosis of bone metastasis and inflammation. In this study, we clinically investigated optimal imaging parameters and scan timing of bone marrow with healthy volunteers as well as a potential of SPIO for the differential diagnosis with patients. Optimal imaging parameters and scan timing were short TI inversion recovery and at 3 hours after a ferucarbotran injection. SPIO enhanced MRI could detect bone metastasis in patients at a clinically approved liver imaging dose.