Dynamic Contrast Enhanced MRI of Synovium in Rheumatoid Arthritis Patients: Response to Intra-articular Therapy and Relationship to Magnetization Transfer Contrast
Kotys M, Wilson M, Gupta S, Thomasson D, Goldbach-Mansky R, Yao L
In patients with rheumatoid arthritis (RA) dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) may yield information about disease activity not reflected by changes in synovial volume. We examined changes in synovium occurring after intra-articular steroid therapy as reflected by standardized kinetic parameters derived from DCE-MRI. We examined the relationship of these parameters and magnetization transfer contrast (MTC) in synovium, hypothesizing that MTC might serve as a marker for more chronic synovial pannus. Our preliminary results, however, did not support this hypothesis. Intra-articular therapy led to consistently reduced synovial volume and spatially variable decreases in Ktrans.