The Reliability of Presurgical fMRI Language Lateralization in Patients with Primary Brain Tumors and Prior Surgery
Peck K, Bogomolny D, Petrovich N, Hou B, Tabar V, Gutin P, Holodny A
Memorial Sloan-Kettering Cancer Center, Memorial Sloan-Kettering Cancer Center
The Intracarotid Amobarbital Procedure (known as the WADA test) is currently the gold standard for establishing hemispheric dominance for language. However, due to its invasive nature, it is hoped that functional MRI, a non-invasive, imaging method, will replace the WADA test. We investigated data obtained from glioma patients with and without prior surgery and characterize the effects of such on the laterality index using fMRI. Despite the presence of tumor and artifact from previous surgery, the effects of tumor and surgical MR artifact were not be sufficient to affect the overall hemispheric measurement of LI and fMRI revealed the expected left hemispheric dominance from both groups.