Abstract #0710

Nezamzadeh M, Cameron I

Restricted diffusion of water molecules in human brain was examined at high b-values over a range of diffusion times to evaluate the apparent diffusion coefficients from the signal decays. Reliable diffusion information requires the removal of Rician noise bias from the decay particularly at high b-values with low SNR and a multi-component analysis. Using this approach, we observed the three major components in the spectrum of diffusion coefficients from the voxel signal decay and small diffusion time dependence for the smallest diffusion coefficient, which has not previously been reported. This observation was compared with the exchange theory for a human model.