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Abstract #0713

Extension of the Diffusion Orientation Transform (DOT) to Multiexponential Signal Attenuation

Vemuri B, Blackband S, Ozarslan E
University of Florida

The diffusion orientation transform (DOT) enables the estimation of water displacement probability profiles from high angular resolution diffusion-weighted MRI data. The method assumes independent monoexponential signal attenuations along different directions if a single spherical shell is sampled. When several concentric shells in q-space are sampled, the transform can trivially be extended to multiexponential signal attenuations. Although estimated fiber orientations seem unaffected, the proposed extension of the DOT improves the resolution of individual fiber populations. The method has the potential to yield a significant reduction in the required number of acquisitions for 3-dimensional q-space imaging.