Greater Blood Flow Reduction in Mild Diffuse Lewy Body Disease than in Mild Alzheimer's Disease
Fong T, Press D, Alsop D
Beth Israel Deaconess Medical Center
Arterial Spin Labeling(ASL) blood flow abnormalities in subjects diagnosed with mild Diffuse Lewy Body Disease(DLBD) were compared to normal controls and subjects with mild Alzheimers Disease. Blood flow abnormalities were similar in spatial distribution for the two dementias but the magnitude of the abnormality was more pronounced in the DLBD patients despite lower impairment. These results suggest ASL blood flow MRI may have low specificity for differentiating these two common dementias and that cholinergic dysfunction, which is greater in DLBD than AD, may be related to cortical flow abnormalities.