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Abstract #0795

A synthetic data set for validation of tracer kinetic modelling and model-driven registration in DCE-MRI

Parker G, Buonaccorsi G
University of Manchester

Analytical techniques for DCE-MRI would benefit from validation against ground truth, but patient data is generally unsuitable for this purpose. We have therefore developed a framework for generating synthetic DCE-MRI data sets that includes the incorporation of an appropriate kinetic model and the addition of motion and noise. We have applied tracer kinetic model fitting and kinetic model-driven registration to a simple synthetic data set generated using this framework, with positive results. We propose that synthetic data of this type will prove invaluable for validating DCE-MRI techniques, particularly when these are to be used in clinical trials.