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Abstract #0848

MR as a Biomarker in Clinical Trials

Evelhoch J
Amgen, Inc.

Imaging is a powerful biomarker that can provide information about many biological/pathobiological processes. MR can serve as a biomarker in many diseases including multiple sclerosis, cancer, arthritis, atherosclerosis and others. Examples of how MR is used in clinical trials developing human therapeutics will be presented. However, prior to use as a biomarker, it must be demonstrated that the MR method is qualified for its intended use. Public-private partnerships among industry, government bodies, academia and not-for-profit organizations could both reduce the cost and speed the process of developing and qualifying MR biomarkers. Ongoing consortia involving MR biomarkers will be considered.