Spinal Cord MT Imaging Correlates with Somatosensory Evoked Potentials in Adrenomyeloneuropathy
MAHMOOD A, ABI-RAAD R, SMITH S, TRESCHER W, RAYMOND G, VAN ZIJL P, MOSER H
JOHNS HOPKINS UNIVERSITY, KENNEDY KRIEGER INSTITUTION
CSF normalized MTw imaging (MTCSF) showed sensitivity to neurological disability and quantitative sensory-motor tests in Adrenomyeloneuropathy, the adult form of X-ALD. Our purpose was to determine the association between central abnormalities detected by Somatosensory evoked potential (reflective of myelin integrity) of upper and lower limbs and dorsal column MTCSF. A significant positive correlation between each subjects mean dorsal column MTCSFint value and SSEP of central latency and interpeak latency was seen. We conclude that abnormalities seen by conventional SSEP of care are corroborated by imaging findings and thus corroborate each other in the in vivo detection of non-inflammatory demyelinating pathology.