Abstract #0901

O'Neill J, Levitt J, Lanphier E, Bailey C, Gurbani S, Alger J, Caplan R

MRS abnormalities are known in childhood epilepsy, but are understudied in relation to use of language to organize and formulate thoughts, formal thought disorder (FTD). We acquired 1H MRSI (TR/TE = 2300/272 ms) from widespread extrafocal brain regions in children with Complex Partial Seizures (CPS) and age-matched controls. In CPS, below-normal NAA/Cr and NAA/Cho and above-normal Cr and Cho were registered in bilateral parietal lobes and right striatum. In CPS in left parietal lobe, cortical NAA/Cr and white-matter Cr correlated with FTD. Extrafocal neuron damage (NAA) and gliosis (Cr, Cho) in pediatric CPS may contribute to thought disorder.