Evaluation of the Simplified Method for Mapping Cerebral Metabolic Rate of Oxygen Based on 17O NMR Approach
Zhang N, Zhu X, Chen W
University of Minnesota
Various factors that may have impacts on the simplified 17O2 approach for CMRO2 measurement are extensively studied. The simulation results validate the simplified method in measuring CMRO2 in relative large ranges of physiologic/pathologic conditions as well as different experimental environments. Comparisons between the linear and quadratic fitting models confirm the notion that quadratic fitting gives more accurate but less reliable results whereas linear fitting gives less accurate but more reliable results. However, there is no statistic significance to distinguish the linear fitting model from the quadratic model in the variation range of the parameters examined.