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Abstract #0984

Examination of White Matter Abnormalities in Cocaine Dependence Using Multi-slice T2 Relaxography

Mueller B, Specker S, Vidarsson L, Lim K, Pauly J, Wozniak J
University of Minnesota, Center for Magnetic Resonance Research

Neuroimaging studies have found white matter abnormalities in cocaine dependent subjects. Other magnetic resonance techniques for examining white matter have recently become available, and have the potential to provide complimentary information about the underlying pathophysiology of cocaine use. T2 relaxography provides a quantitative method for measuring the signal from water trapped in the myelin sheath. We report preliminary results from T2 relaxography data from ten cocaine dependent subjects and eight healthy controls. These preliminary suggest differences in white matter between CD subjects and controls.