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Abstract #1007

Can texture analysis of MR images discriminate the severity of hepatic fibrosis? A patient study with histological correlation

Hollingsworth K, Lomas D, Davies S
University of Cambridge

Hepatic fibrosis is not usually directly observable in MR images until the onset of end-stage cirrhosis. A training set of healthy volunteers and end-stage cirrhotic patients had previously been used to identify discriminating texture parameters. In this work these parameters are applied to an evaluation set of healthy subjects and patients with hepatic fibrosis of varying severity, confirmed on liver biopsy: the effect of changing the discretization step of the texture analysis is evaluated. The evaluation set confirms that the parameters can discriminate grades 0-2 fibrosis from fibrosis grades 3-6 but low numbers in the intermediate grades prevent further discrimination.