Impact of Partial Volume Effect on Fiber Coherence Index (FCI) Calculation: A Simulation Study
Srinivasan G, Zhou X, Poonawalla A
University of Illinois at Chicago, University of Illinois Medical Center
Fiber coherence index (FCI) was recently introduced as a vector-based diffusion tensor parameter for characterizing tissue structural integrity. This parameter is sensitive to partial volume effect because of a spatial vector correlation calculation. In this simulation study, we have analyzed the impact of partial volume effect on FCI for three types of fibers (straight, bent, and branching/crossing fibers) with varying sizes between 0.5 and 6 mm. The results provide a number of useful guidelines to properly use FCI on specific fibers for clinical applications, when the partial volume effect is a concern.