Neural Correlates to the Episodic Memory Continuum from Health to Alzheimers Disease
Wunderlich A, Grn G, Riepe M
Behaviorally, episodic memory in health and Alzheimers Disease (AD) is thought to reflect a continuum. If so, neural correlates should exist which reflect this. This study was undertaken to look for neural correlates of episodic memory continuum in appropriate subjects. Twelve patients with mild AD and 24 healthy subjects, divided into two subgroups reflecting memory task performance were investigated with fMRI while performing an episodic memory task. Analysis was designed to reveal areas with increasing activation from high-performing healthy subjects to AD patients. We identified four areas: parahippocampal gyrus, hippocampus proper, lingual and fusiform gyri and inferior temporal gyrus.