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Abstract #1158

Imaging rCBF Changes in Response to Insulin-Induced Hypoglycemia at 3T Using Three-Coil CASL

Auerbach E, Ugurbil K, Seaquist E, Rao J
University of Minnesota

Previous studies have used PET to map changes in regional cerebral blood flow (rCBF) in response to hypoglycemia, but the spatial resolution of PET is typically low (8-10 mm). Higher resolution would be advantageous for localizing smaller structures involved in hypoglycemia detection and counterregulation. In this study, three-coil CASL was implemented and utilized on a 3 Tesla clinical scanner to determine if changes in rCBF detected at a resolution of 2 2 3 mm could be used to identify those regions that are activated in response to hypoglycemia.