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Abstract #1172

Rate of Myocardial Contrast Enhancement with Extracellular Contrast Agent and Relationship to Perfusion Reserve

Stillman A, Rickers C, Murthy N, Jerosch-Herold M
Cleveland Clinic Foundation, University of Minnesota

The rate of myocardial contrast enhancement is sensitive to changes in myocardial blood flow, but this relationship has not been systematically investigated. Starting with the central volume principle we derive an approximation between blood flow and rate of contrast enhancement, which is used to estimate the myocardial perfusion reserve, a clinically important parameter for assessing the hemodynamic signifcant of coronary lesions.