Abstract #1206

Dendy J, Paschal C, Gore J

We examine the effects of myocardial hypertrophy on myocardial microvascular volume and blood oxygenation level changes using iron oxide nanoparticles and adenosine. By measuring the changes in R2* at baseline and with the administration of adenosine, and repeating the measurements in the presence of the intravascular iron oxide contrast agent, blood volume maps and blood oxygenation maps were developed. R2* maps with and without adenosine, before and after the administration of monocrystalline iron oxide nanoparticle were calculated in healthy rats and rats with drug-induced myocardial hypertrophy. The method demonstrated a decrease in response of hypertrophic myocardium to adenosine.