Comparison of hyperpolarized 3-He administration methods in healthy and diseased subjects
Mills G, Fleming S, Fichele S, van Beek E, Wild J, Woodhouse N
Sheffield Teaching Hospitals NHS Trust
To determine the physiological effects and responses to hypoxic and anoxic breath holds containing 3-He in 2 patient groups (Healthy and Emphysema) using two separate methods of administration; the first a bag and tube containing 3-He and N2, the second a computer controlled applicator device driven by a ventilator. Oxygen saturation (SpO2) was measured for the first minute following each breathing maneuver. The healthy group showed the largest mean drop of 4%. While the group with emphysema showed only a 1% drop in SpO2. None of the participants reported any ill effects for either method.