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Abstract #1348

Characterisation of lipopolysaccharide induced pulmonary oedema in rats by MRI

Changani K, Hotee S, White A, Bhakoo K, Bell J

Lipopolysaccharide (LPS) is an ubiquitous endotoxin which produces many of the pathophysiological features of acute respiratory distress syndrome (ARDS) including; rapid pulmonary oedema development, and pulmonary neutrophil influx. An understanding of the processes and mechanisms in early phase ARDS is essential for the development of therapeutic intervention. This study characterises the regional development of oedema and quantifies its volume over time (<4 hours post LPS challenge).