Abstract #1407

Li D, Park J, Rhee T, Omary R, Larson A, Schirf B, Cashen T, Shin W, Carroll T, Prasad P

We tested the hypothesis that MRI can successfully detect changes in renal function at the time of renal percutaneous transluminal angioplasty (PTA) in a swine model of renal artery stenosis (RAS). Before and after X-ray-guided PTA, pigs were imaged on a 3.0 T MR scanner to obtain functional kidney measurements. Glomerular filtration rate (GFR), extraction fraction (EF), and the renal blood flow (RBF) were measured pre- and post-procedure. Increases in GFR and EF following PTA were statistically significant, but changes in RBF were not. This combined X-ray/MR approach is now possible in a clinical setting with new hybrid X-ray/MR scanners.