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Abstract #1482

Methylphenidate administration during adolescence produces long-term effects in adult rat brain: a 1H MRS in vivo study

Podo F, Laviola G, Canese R, Adriani W
Istituto Superiore di Sanit

Long-term effects of methylphenidate (a drug currently used for treatment of children affected by attention deficit hyperactivity disorder) were investigated in selected brain regions of adult rats, following exposure to this drug during adolescence. Our data indicate that adolescent MPH exposure produces long-term metabolic changes in reward-related circuits. These enduring MRS-detectable biochemical modifications may perhaps account for the finding of reduced basal behavioral impulsivity in the adult rat.