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Abstract #1495

Genotype Specific Alterations Detected in the Neurochemical Profiles of Aged Transgenic Mouse Models of Alzheimer's Disease

Bliss R, Poduslo J, Curran G, Wengenack T, Marjanska M, Garwood M, Jack, Jr. C, Ugurbil K, Henry P
University of Minnesota

Proton magnetic resonance spectroscopy offers a non-invasive way to quantify many metabolites in vivo. Metabolite levels are sensitive to different in vivo pathologic processes at the molecular or cellular level; e.g. myo-inositol (mIns) and taurine are thought to be markers for osmotic stress or astrogliosis. Murine models of Alzheimers disease (AD) have been created by inserting human mutations associated with abnormal processing of amyloid &[beta] protein. These mutations of amyloid precursor protein (APP) and presenilin (PS) 1 or 2 produce hereditary AD in humans. Recently spectroscopic analysis of single transgenic APP, and double transgenic PS2APP and APP-PS1 mice brains showed neurochemical profiles which deviate from that seen in wild-type mice as the transgenic mice age. The purpose of this study was to compare the levels of the metabolites in question, mIns and taurine, in different mouse models of Alzheimers disease: APP, PS1, APP-PS1 and wild-type. We hypoth