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Abstract #1518

First report of Diffusion Tensor Imaging of the murine eye

Chandra S, Forder J, Padgett K
University of Florida

The main objective of our study was to determine the feasibility of DTI methods in the murine eye for neuronal fiber orientation, an uncharted area so far. We have acquired extremely high resolution datasets in excised mouse eyes of up to 20 microns isotropic so as to image 6 individual retinal layers. Some of the major observations of this study were that diffusion in the retina is anisotropic and the direction of diffusion is along the retinal layers rather than across layers. This study will aid future ocular studies involving macular degeneration, diabetes and glaucoma.