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Abstract #1548

Variability In qCBF Obtained From Deconvolution-based Perfusion-Weighted MR Techniques

Niven D, Dzialowski I, Demchuk A, Subramaniam S, Dickhoff P, Kosior J, Frayne R
Seaman Family MR Centre, Foothills Medical Centre, Calgary Health Region

We sought to evaluate the inter- and intra-observer variability, as well as the effect of AIF and ROI selection on qCBF variability. This study was a retrospective cohort study in which twelve patients with acute ischemic stroke (AIS) were imaged on a 3T MR scanner (DWI and PWI imaging). ROI selection (p < 0.001), embolic AIS etiology (p < 0.001), and observer (p = 0.034) significantly impact overall qCBF variability. AIF selection, i.e., manual versus semi-automated, does not contribute significantly to overall variability. There is significant intra- and inter-observer variability in qCBF based on the results of simple regression analyses.