Q-space analysis of intracellular water diffusion in cultured cells
Trouard T, Divijak J, Gillies R, Galons J, Lope-Piedrafita S, Harkins K
University of Arizona
The complexity of biological tissues, with multiple compartments each with its own diffusion and relaxation properties require complex formalisms to model water signal in most MRI or MRS experiments. In this communication we take advantage of a Gd-DTPA induced magnetic susceptibility shift of the resonance frequency of extracellular water to perform a q-space analysis of the intracellular water diffusion using the signal originating exclusively from the intracellular space.