The effects of deoxyhemoglobin and flow rate on R2' in hindlimb perfused skeletal muscle
Damon B, Sanchez O
Hindlimb perfusion of mice with bovine erythrocytes and Krebs-Henseleit buffer was use to study the effects of changing flow rate and blood oxygenation on relaxation parameters. Despite increasing flow rate, blood volume measured using VASO in the skeletal muscle did not increase. Arterio-venous oxygen difference was observed at higher flow rates, as well as a decrease in venous deoxyhemoglobin. This was significantly associated with lower R2. This study confirms that in skeletal muscle tissue oxygenation is the most important parameter affecting relaxation parameters.