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Abstract #1742

Functional Colonoscopy using Dark Lumen DCE-MRI

Quarles C, McIntyre J, Gorden D, Lepage M, Yankeelov T, Price R, Matrisian L, Gore J
Vanderbilt University, Vanderbilt University

Dark lumen-based colonoscopy has demonstrated reasonable success in detecting colon polyps. The purpose of this study is to develop a new approach to eliminate the colon lumen signal intensity while improving polyp detectability in Min mice using oil as a back-filling agent. The largest dimension of the smallest polyp detected was 1 mm. We also demonstrate the potential of dynamic contrast enhanced MRI to characterize the polyp microenvironment.