Characterization of rat glioma models by magnetic resonance angiography
Kshirsagar P, Pye Q, Tesiram Y, Doblas S, Saunders D, Towner R
Oklahoma Medical Research Foundation
Malignant gliomas, which are the most common primary brain tumors, still lead to poor prognosis because of the difficulty of an early and accurate diagnosis. One of the problems is that the presence of new blood vessels, which is an absolute requirement for tumor growth and spread, must be well documented. Indeed, it has been shown that a dramatically increased angiogenesis is characteristic of high-grade gliomas. In this point of view, magnetic resonance angiography (MRA) can be used as a non-invasive tool to assess angiogenic behavior of gliomas and perhaps provide better diagnosis. We conclude from our study that specific angiogenic patterns of different glioma models (C6, F98 and 9L/LacZ) can be revealed by MRA, which could be a useful method to differentiate gliomas in human diagnosis.