Abstract #1791

Kumar V, Jagannathan N, Kumar R, Das S, Jindal L, Thulkar S, Gupta S, Dwivedi S, Hemal A, Gupta N, Nayyar R

The positive biopsy rate of ultrasound guided sextant biopsy is low especially in patients with PSA < 10 ng/mL. The present study was carried out to evaluate the sensitivity and specificity of 3D 1H MRSI directed TRUS guided biopsies in a large cohort of patients categorized on the basis of PSA level (0-10 ng/mL, 10-20 ng/mL, > 20 ng/mL). TRUS guided biopsy was performed by using MRSI derived x- and z-coordinate of the suspicious voxel. The overall sensitivity and specificity of MRSI directed TRUS guided biopsies was 98% and 40% respectively, with PPV=43%, NPV=97 %. The pick up rate of prostate cancer increased with MRSI focused biopsy.