3D 1H MRSI Based TRUS Guided Biopsies in Men with Suspected Prostate Cancer
Kumar V, Jagannathan N, Kumar R, Das S, Jindal L, Thulkar S, Gupta S, Dwivedi S, Hemal A, Gupta N, Nayyar R
All India Institute of Medical Sciences
The positive biopsy rate of ultrasound guided sextant biopsy is low especially in patients with PSA < 10 ng/mL. The present study was carried out to evaluate the sensitivity and specificity of 3D 1H MRSI directed TRUS guided biopsies in a large cohort of patients categorized on the basis of PSA level (0-10 ng/mL, 10-20 ng/mL, > 20 ng/mL). TRUS guided biopsy was performed by using MRSI derived x- and z-coordinate of the suspicious voxel. The overall sensitivity and specificity of MRSI directed TRUS guided biopsies was 98% and 40% respectively, with PPV=43%, NPV=97 %. The pick up rate of prostate cancer increased with MRSI focused biopsy.