MRI of mouse experimental colitis using ultrasmall superparamagnetic iron oxide particles
Larsson A, Melgar S, Rehnstrm E, Svensson L, Michaelsson E, Hockings P, Olsson L
The aim of the present study was to investigate ultrasmall superparamagnetic iron particles (USPIO) as a possible inflammation biomarker by using MRI in an experimental mouse inflammatory bowel disease model. A dose of 1000 or 500 mmol/kg Sinerem, and a T2* sensitive sequence at 4.7 T were used. MRI and histological results demonstrate that USPIOs accumulate in macrophages in the serosa in the proximal part of the colon wall in DSS exposed mice injected with the high dose of USPIOs. In conclusion, USPIOs seem to be a promising inflammatory biomarker in experimental mouse colitis.