Relaxometry of new nanoparticles at 3 Tesla: Effect of core size and coating on r1, r2, r2*
Kaul M, Parak W, Nikolic M, Weller H, Bruns O, Ittrich H, Adam G, Dahnke H, Bigall N
University Medical Center Hamburg-Eppendorf
Molecular imaging is one of the major interests in modern diagnostic medicine. New contrast agents with shaped functionality and strong relaxivities are desired. In this study new nanoparticles with different core sizes and coatings were examined and tested. The applied sequences together with the analyzing tools have shown to be an effective package to determine in-vitro relaxivities of new nanoparticles on a clinical 3T scanner. The influence of the core size and the coating on the relaxivities has been shown.