Abstract #1842

Ke T, Ye F, Jeong E, Wang X, Lu Z

Polymers have become effective carriers in drug delivery due to advantages such as enhanced tumor accumulation. However the in vivo delivery mechanism of polymer drug conjugates is not clear based on current biopsy-based method. We intend to explore non-invasive monitoring of in vivo drug delivery with contrast-enhanced MRI and quantitative T1 mapping. MRI data clearly revealed the sized effect of the conjugates on their pharmacokinetics; and quantitative T1 mapping is effective to visualize the dynamic accumulation of the conjugates in the solid tumor tissue. Its promising for future study of non-invasive monitoring in drug delivery with polymeric drug conjugates.