Single Cell MRI with FIESTA: Quantitative Benefits of 3T vs 1.5T
Rutt B, Ramadan S, Heyn C, Foster P
Robarts Research Institute
In this study we investigate the use of higher magnetic field strength to allow for high resolution FIESTA image data acquisition in reasonable scan times, and the impact of this strategy on contrast generated by iron labeled cells. Mice were injected with MPIO-labeled, brain-seeking metastatic breast cancer cells and imaged at 1.5 and 3T with 3DFIESTA. The contrast generated by iron labeled cells was the same in 1.5 and 3T images matched for SNR and spatial resolution and was greater in higher resolution 3T images. A greater than linear increase in SNR resulted from 1.5T to 3T.