Intra-Individual Comparison of 0.5 & 1.0M contrast agents in the evaluation of Chronic Thrombo-Embolic Pulmonary Hypertension
Woodhouse N, Wild J, van Beek E, Elliot C, Griffiths P, Paley M, Kiely D
University of Sheffield
We compared 0.5M Gd-DTPA (Magnevist) and 1.0M Gd-BT-D3OA (Gadovist) in both high-resolution and dynamic time resolved MRA in chronic thromboembolic pulmonary hypertension (CTEPH). Patients were scanned twice within 48 hours receiving the same contrast dose for each examination. There was greater separation of pulmonary and systemic peaks in the Gd-BT-DO3A examinations compared to Gd-DTPA. Parametric comparison between the time-resolved examinations revealed better delineation of the pulmonary arterial and venous circulations using Gd-BT-DO3A. The more compact bolus-profile of Gd-BT-DO3A compared to that of Gd-DTPA results in less contamination of the arterial phase image by cardiac motion and pulmonary-venous and systemic vasculature.