Peripheral MR Angiography with Gadobenate Dimeglumine: Results of a Large-scale Multi-institutional Experience
Thurnher S, Ballarati C, Claussen C, Schneider G, Schoenberg S, Pirovano G, Bongartz G, Parker J
University of Vienna
Patients with peripheral arterial disease (n=272) underwent DSA and MRA (2D-TOF sequence followed by 3D-SPGRE sequence after 0.1 mmol/kg gadobenate dimeglumine) within a 30 day period. Both exams covered from the aortic bifurcation to the trifurcation, and DSA results were used as the gold standard. According to the three blinded reviewers the technical failure rate of TOF-MRA was 6.2%-18%. This rate was significant lower (p< 0.001) on the CE-MRA exam (2.5%-3.4%), a rate approaching that of DSA (1.4%). Sensitivity for detection of significant disease (50%) ranged from 33.2% to 62.8% and from 54% to 80.9% for TOF-MRA and CE-MRA, respectively. When comparing CE-MRA to TOF-MRA, significant increases (p< 0.001) in specificity (74.3-88.9% to 89.7-95.3%) and accuracy (68-77.3% to 85-87.5%) were noted. Significantly better reproducibility (p< 0.00001) was also demonstrated for CE-MRA vs TOF-MRA (82% agreement, k-value: 0.66 vs 65.2% agreement; k-value: 0.47).