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Abstract #1962

Contrast-Enhanced MRI of Occlusive Arterial Disease

Wright G, Strauss B, Graham J, Moody A, Dick A, Munce N, MacMillan E, Truong M, Qiang B, Leung G, Anderson K
University of Toronto, Sunnybrook and Women's College Health Sciences Centre

In this study we investigate the behavior of two different MRI contrast agents (Omniscan and Clariscan) for characterizing occlusive arterial disease attributes such as inflammation and neovascularization in an animal model of total femoral artery blockage. The relative distribution volume of each contrast agent was measured in occlusive lesions of varying age. Consistent with the literature, the results suggest that endoluminal neovascularization increases over the initial 10 weeks and is followed by a progressive collapse of these neovessels. An increase in permeability and associated interstitial space is also experienced over the initial 3-5 weeks and subsides over time.