Meeting Banner
Abstract #1978

In vivo 2D mapping of cardiac high energy phosphates in the mouse

Flgel U, Jacoby C, Gdecke A, Schrader J
Universittsklinikum Dsseldorf, Heinrich-Heine-Universitt

This study was aimed at developing a protocol for an integrated energetic and functional characterization of transgenic mouse models with cardiomyopathies. Using acquisition-weighted 2D 31P CSI at a field strength of 9.4 T, we were able to acquire spectra from the left ventricle of good quality within a reasonable acquisition time of about 75 min. The obtained data were validated against perchloric acid extracts of the same hearts. Analysis of a transgenic mouse line which has been shown to develop signs of heart failure revealed that cardiac dysfunction was accompanied by an impaired energy homeostasis over the entire left ventricle.

Keywords

spectracardiacheartmouseacquisition