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Abstract #2005

Magnetic Resonance Microscopy of a Mouse Model of Attention-Deficit-Hyperactivity Disorder: Role of D4 dopamine receptors

Benveniste H, Ma Y, Lee H, Grant S, Blackband S, Hof P, Marcelo R
Brookhaven National Laboratory

Studies have shown a wide variety of genetic polymorphisms in attention-deficit-hyperactivity Disorder (ADHD). Genetically engineered mice models are therefore important in studying ADHD. Here we use MR microscopy to characterize brain morphometry in a recently developed mouse model of ADHD that involves neonatal disruption of central dopaminergic pathaways in CF-1 mice as well as in mice deficient of the dopamine-4 receptor.