MRI Morphometry of the Brain in a Longitudinal Study of Depression
Ahdidan J, Rosenberg R, Ravnkilde B, Rodell A, Videbech P, Mouridsen K, Hviid L
University Psychiatric Hospital in Aarhus
A five year longitudinal study of depression has been performed in order to examine structural morphometric differences of the whole brain, between patients and controls over time. We propose using morphometric methods, such as deformation based morphometry (DBM), to automatically identify structural shape changes of the whole brain associated with depression. These methods can detect changes with a high resolution and accuracy without a priori hypothesis. We present a pilot study performed on five patients and seven controls. Preliminary results have shown a significant change over time between the two groups in the hippocampus and the cerebellum.