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Abstract #2089

Structural Abnormalities in Posterior Fossa Brain Tumor Survivors: a Voxel-Based Morphometry Study Based on Free-Form Deformation

Zhang Y, Zou P, Mulhern R, Ogg R, Butler R
St. Jude Children's Research Hospital, University of Tennessee Health Science Center

We used voxel-based morphomotry (VBM) to compare brain structure between survivors of posterior fossa brain tumor (PFBT) and controls to test the hypothesis that focal morphological abnormalities in PFBT patients account for altered brain activation patterns during a continuous performance test (CPT). Free-Form Deformation improved the spatial normalization accuracy for the PFBT patients with surgical voids and enlarged ventricles. Morphological differences were detected, but not located where altered activation occurred, contrary to our hypothesis. Morphological differences in the thalamus and white matter of the internal capsule and corpus callosum may have affected CPT activation indirectly.