The Early MS Pathology in the Corpus Callosum by Atrophy, Magnetization Transfer and Diffusion Tensor Measures at 3T in Patients With a Clinically Isolated Syndrome and a Positive MRI
Singel D, Corboy J, Brown M, Miller D, Bennett J, Simon J
University of Colorado HSC
Baseline characterization of corpus callosum from the earliest disease, after a clinically isolated syndrome in patients with a positive MRI reveals no or minimal change outside focal lesions in the normal appearing white matter (NAWM) by diffusion tensor(fractional anisotropy and apparent diffusion coefficient) and magnetization transfer at 3T. As disease progresses, increased abnormality is detected in the NAWM. As a sizeable fraction of these callosa contain fibers that are at risk for injury as they connect to distant (non-callosal) focal MS lesions, this pathology is likely too dilute to measure within the non-selective tissue class called NAWM.