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Abstract #2117

Quantifying the BOLD Contribution in CBV-Weighted fMRI at 9.4T

Yang Y, Gitajn L, Rea W, Lu H, Stein E
National Institute on Drug Abuse

In fMRI employing iron oxide contrast agent, there are two competing factors that contribute to the fMRI signal: one is the BOLD effect, and the other is the superparamagnetic effect of iron oxide. At high field, the BOLD contamination can be a significant component in CBV-weighted fMRI. This work is intended to determine 1) the optimal iron dose in CBV-weighted fMRI and 2) BOLD contribution in CBV-weighted fMRI signal. We further quantified the intra- and extra-vascular BOLD effect in spin echo fMRI at 9.4T.