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Abstract #2302

A comphrehensive fat composition measurements in mice In vivo with High Field MR Systems

Liu H, Miller C, Hargreaves R, Mu J, Zhang B, Williams D
Merck Research Labs

An MR based assay has been implemented to provide a comprehensive characterization of body fat composition. A valuable set of body composition parameters have been obtained from both lean and ob/ob mice (N=4/group). These readouts, total fat volume, visceral volume, liver fat content, IMCL, etc. are not easily accessible from a living animal with other conventional measurement techniques. A more complete characterization of the body fat changes in progression of obesity and response to various therapeutic agents is now possible in the same animal.